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目的 探讨阶段性改变模式在中青年冠心病患者中的应用效果。方法 选取2017年6月-2019年6月我院心内科收治的80例中青年冠心病患者为研究对象,采用随机数字表法将其分为对照组和观察组各40例,对照组予以常规护理,观察组在常规护理基础上加用阶段性改变模式进行干预。比较2组自我效能、健康素养、疾病相关知识掌握程度及焦虑评分的差异。结果 干预后,观察组自我效能、健康素养、疾病相关知识掌握程度评分均明显高于对照组(t=2.436,P=0.015;t=8.569,P<0.001;t=13.890,P<0.001),SAS评分明显低于对照组(t=9.712,P<0.001)。结论 阶段性改变模式应用于中青年冠心病患者中的干预效果较好,在明显提高患者自我效能,减轻其焦虑情绪的同时,对其健康生活方式及疾病相关知识掌握程度的改善均具有重要价值,可考虑推广应用。 相似文献
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《Sleep medicine》2021
BackgroundTheoretical models argue that coping reduces stress responses, yet no studies have tested whether coping moderates the prospective stress effects on sleep in daily life.PurposeThis study tested if coping moderates the stress-sleep association using a daily, intensive longitudinal design across 7–12 days.Methods326 young adults (Mage = 23.24 ± 5.46) reported perceived stress and coping (problem-focused, emotional-approach, and avoidance) every evening between 20:00–02:00, providing over 2400 nights of sleep data and 3000 stress surveys from all participants. Actigraphy and sleep diaries measured total-sleep-time and sleep efficiency. Multilevel models tested the interaction effects of within- and between-person stress and coping on sleep.ResultsWithin-person problem-focused and emotional-approach coping moderated the within-person stress effects on actigraphic total-sleep-time (both p = 0.02); higher stress predicted shorter total-sleep-time only during high use of problem-focused or emotional-approach coping (both p = 0.01). Between-person avoidance moderated the between-person stress effect on actigraphic total-sleep-time (p = 0.04); higher stress predicted shorter total-sleep-time for high avoidance coping (p = 0.02). Within-person emotional-approach coping buffered the between-person stress effect on actigraphic sleep efficiency (p = 0.02); higher stress predicted higher sleep efficiency for high emotional-approach coping (p = 0.04).ConclusionsThis study showed that daily coping moderates the effects of evening stress on sleep that night. More efforts to cope with stress before bedtime had a short-term cost of shorter sleep that night. However, high use of emotional-approach coping buffered the impact of stress to promote sleep efficiency. 相似文献
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目的 评价以问题为基础的教学法(problem-based learning,PBL)联合影像后处理技术在神经外科教学查房中的应用效果。方法 选择神经外科典型病例,以病例为基础,以问题为导向布置课前预习内容,联合影像后处理技术在教学查房中以导向问题为主线实施教学培训,与传统教学方法相比评价教学效果。结果 PBL联合影像后处理技术教学查房模式和传统讲授教学查房模式的学员理论考试成绩分别为92.53±2.17分、81.40±6.17分,临床诊疗考核成绩分别为91.10±1.97分、79.60±3.27分,P值分别为<0.001、<0.001,差异有统计学意义。接受PBL联合影像后处理技术教学模式的学员对教学方式的认可度、增加学习兴趣、利于神经科思维,P值分别为0.013、0.024、0.035。结论 PBL联合影像后处理技术可有效提高教学查房效果,帮助学员提高对基础知识的理解能力,抓住神经外科疾病的关键点加速神经外科诊疗思维能力的形成。 相似文献
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ObjectiveNeuropsychiatric lupus (NPSLE), a manifestation of the autoimmune disease systemic lupus erythematosus (SLE), is characterized by psychiatric symptoms including anxiety and depression and upregulated autoantibodies. The B6.Nba2 spontaneous mouse model develops SLE, but has not previously been tested for NPSLE.MethodsWe investigated the NPSLE phenotype in male and female B6.Nba2 mice (n = 12 each) and age- and sex-matched B6 controls (n = 10 each) via behavioral assessments for anxiety, depression, and memory deficits. Serum anti-dsDNA, anti-nRNP, anti-DWEYS peptide reactive IgG autoantibody levels and soluble TWEAK levels were determined by ELISA. Hippocampal regions were stained for activated microglia and neurons.ResultsBoth male and female B6.Nba2 mice showed elevated anti-dsDNA IgG, anti-nRNP IgG and anti-DWEYS reactive antibodies, elevated serum soluble TWEAK levels, and a strong anxiety and depression phenotype (p < 0.05–0.0001). Male B6.Nba2 mice developed this phenotype at a slightly older age than females. Female B6.Nba2 mice displayed reduced numbers of neurons in the hippocampal region compared to female B6 controls (p < 0.05).ConclusionThe B6.Nba2 mouse model recapitulates many known NPSLE phenotypes, making it a promising model to investigate the development of NPSLE in the context of SLE. 相似文献
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Zahra Hassannejad Shayan Abdollah Zadegan Alexander R. Vaccaro Vafa Rahimi-Movaghar Omid Sabzevari 《Injury》2019,50(2):278-285
Background
The complex pathophysiological events occurring after traumatic spinal cord injuries (TSCI) make this devastating trauma still incurable. Peptide amphiphile (PA) hydrogels are nanobiomaterials displaying desirable properties for application in regenerative medicine because they are absorbable, injectable, allowing biofunctionalization, controlling release of trophic factors and mimic extracellular matrix (ECM). In this study, we explored the potentiality of the IKVAV-functionalized PA hydrogel to provide a permissive environment for cell migration and growth as well as sustained release of BDNF at the lesion after severe compression injury model.Methods
The IKVAV-functionalized PA was synthesized by automated solid-phase approach and its secondary structure was evaluated by Circular dichroism (CD) spectroscopy. The potential of IKVAV-functionalized PA to self-assemble into nanofibers and hydrogel formation were assessed using transmission electron microscopy (TEM). Release profiles of BDNF from hydrogel and the bioactivity of the released BDNF from hydrogel were determined using ELISA and DRG bioassay, respectively. Severe spinal cord injury was induced using clip compression at T7-T8 vertebral segment. Twenty four hours post-injury the animals were treated by either IKVAV PA hydrogel, BDNF-loaded IKVAV PA hydrogel, BDNF solution or saline. Two and six weeks later, animals were sacrificed and the lesion site was evaluated based on GFAP, CD68 and ß III tubulin immunoreactivity. Also, locomotor recovery was assessed during 6 weeks using Basso, Beattie, Bresnahan (BBB) scoring test.Results
The IKVAV PA arranged into nanofibrous structure and provided a sustained release of BDNF over 21 days while preserved the bioactivity of BDNF. Also, BDNF loading influenced the hydrogel nanostructure resulting in aligned orientation of nanofibers. Injection of BDNF-loaded IKVAV PA hydrogel resulted in a considerable axon preservation and astrogliosis reduction at 6 weeks post-injury without showing any inflammatory reaction. However, the BBB score was not statistically different between different treatment groups.Conclusion
Although the locomotor functional recovery was not observed in this study, the axon preservation and minimal inflammation in animals treated with BDNF-incorporated hydrogel indicate the potentiality of the designed intervention for further evaluations in the path of developing efficient therapies for severe spinal cord injury. 相似文献90.